Human c-fms proto-oncogene: comparative analysis with an abnormal allele.
نویسندگان
چکیده
منابع مشابه
Reassessment of the murine c-fms proto-oncogene sequence.
The c-fms gene encodes the receptor for the macrophage-colony stimulating factor (M-CSF) which promotes the proliferation and survival of cells of the monocytic lineage (1). A cDNA library was constructed from a murine myeloblastic leukemic cell line, BMC-4, in which the c-fms gene was overexpressed (2). Eleven independent full-length cDNAs were isolated after screening with a probe encompassin...
متن کاملThe colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand.
Alterations in genes that function in normal growth and development have been linked to malignant cell transformation. The mononuclear phagocyte colony-stimulating factor (CSF-1 or M-CSF) is a polypeptide growth factor synthesized by mesenchymal cells, which stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. Multiple forms of s...
متن کاملPost-Transcriptional Regulation of Proto-Oncogene c-fms in Breast Cancer
In the development and progression of breast cancers, both the c-fms proto-oncogene (which encodes the tyrosine kinase receptor for CSF-1) as well as CSF-1 (colony stimulating factor1), play an important role. Evidence from transgenic models suggests that c-fms encodes for the sole receptor for CSF-1 (Dai et al, 2002). We and others have found that c-fms and/or CSF1 are expressed by the tumor e...
متن کاملThe protein encoded by the human proto-oncogene c-myc.
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human and other mammalian versions of c-myc. We fo...
متن کاملAutocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging.
Breast cancer cells preferentially home to the bone microenvironment, which provides a unique niche with a network of multiple bidirectional communications between host and tumor, promoting survival and growth of bone metastases. In the bone microenvironment, the c-fms proto-oncogene that encodes for the CSF-1 receptor, along with CSF-1, serves as one critical cytokine/receptor pair, functionin...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1985
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.5.2.422